Tanaka, H.（田中大貴）, Nishina, K.（仁科国之）, Shou, Q.（寿秋露）, Takahashi, H., Sakagami, M., Matsuda, T., Inoue-Murayama, M., Takagishi, H.（高岸治人） (2023). Association between arginine vasopressin receptor 1A ( AVPR1A) polymorphism and inequity aversion. アルギニン・バソプレシン受容体1A ( AVPR1A ) 多型と不公平感回避の関連性 Proceedings of the Royal Society B: Biological Sciences, 290(2000), 20230378. https://royalsocietypublishing.org/doi/10.1098/rspb.2023.0378
Although numerous studies have focused on brain functions related to inequity aversion, few have examined its genetic basis. Here, we show the association between estimated inequity aversion and polymorphisms in three genes associated with human sociality. Non-student adult participants took part in five economic game experiments on different days. Disadvantageous inequity aversion (DIA) and advantageous inequity aversion (AIA) were calculated from behavioural responses using Bayesian estimation. We investigated the association between genetic polymorphisms in the oxytocin receptor (OXTR rs53576), arginine vasopressin receptor 1A (AVPR1A RS3) and opioid receptor mu 1 (OPRM1 rs1799971) and inequity aversion. Regarding AVPR1A RS3, participants with the SS genotype had higher AIA than those with the SL or LL genotypes, but no association was found for DIA. Moreover, we observed no aversion associations for OXTR rs53576 or OPRM1 rs1799971. The results suggest that AVPR1A plays an important role in aversion when one’s own gain is greater than that of others. Our findings may provide a solid theoretical basis for future studies on the relationship between genetic polymorphisms and inequity aversion.